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Description of Bullous Emphysema Using Lung Ultrasound and Comparison to the Characteristics of Pneumothorax

NCT04012359 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 35

Last updated 2022-11-08

No results posted yet for this study

Summary

Chronic Obstructive Pulmonary Disease (COPD) is a frequent disease affecting a growing number of adults in the world which is responsible for a large public health burden through heavy morbidity and mortality.

Emphysema is one of a wide spectrum of pulmonary complications linked to COPD, defined as the abnormal permanent enlargement of the airspaces distal to the terminal bronchioles accompanied by destruction of the alveolar wall. Disease progression is correlated to worsening and enlargement of emphysema lesions, sometimes conflating in sizeable bullae, deleterious to normal mechanical pulmonary function. Bullous emphysema (BE) is sometimes eligible to invasive curative treatment through surgery or interventional bronchoscopy.

Diagnosis of BE relies on computerized tomodensitometry (CT), the gold-standard for evaluating pulmonary parenchyma. However, CT is not always available, and bullous emphysema can present as pneumothorax on chest radiography.

The practice of lung ultrasound is currently growing in respiratory medicine and emergency departments owing to an increasing amount of evidence showcasing its reliability as a diagnostic tool, most notably for pneumothorax and other pleural diseases. Despite BE having been reported to present similarly to pneumothorax in ultrasound, its characteristics have not yet been precisely described.

The primary aim of this study is to describe BE using lung ultrasound. Participants with known BE on CT will undergo a simple ultrasound examination. The secondary aim is to compare the characteristics of BE to those of pneumothorax using lung ultrasound. To achieve this, a second group of participants with currently treated pneumothorax will also undergo lung ultrasound.

Conditions

  • Pulmonary Emphysema

Interventions

DIAGNOSTIC_TEST

Lung ultrasound

Non-invasive external ultrasonography of the chest wall

DIAGNOSTIC_TEST

Chest radiography

Chest radiography to search for visible pleural edge, synonym with persistent pneumothorax

DIAGNOSTIC_TEST

Pulmonary function tests

Pulmonary function evaluation as part of routine care for emphysematous patients

OTHER

Clinical examination

Standard clinical examination performed by investigating physician

Sponsors & Collaborators

  • University Hospital, Rouen

    lead OTHER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2019-06-26
Primary Completion
2021-06-26
Completion
2021-06-26

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04012359 on ClinicalTrials.gov