MedTrace Logo

Hepcidin and Glucose Metabolism

NCT04008147 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 30

Last updated 2025-05-22

No results posted yet for this study

Summary

Gestational diabetes mellitus (GDM), defined as hyperglycemia with blood glucose values above normal but below those diagnostic of DM, and iron deficiency (ID) with or without anemia (IDA) are common during pregnancy. Both disease patterns are associated with an increased risk of complications during pregnancy and at delivery and may have a variety of negative effects on different aspects of child development. Thus, GDM and ID/IDA during pregnancy should be prevented.

Whether iron supplementation with high oral doses acutely increases hepcidin during pregnancy, and whether this acute iron-induced increase in hepcidin decreases insulin sensitivity, is uncertain.

Conditions

  • Iron Deficiency Anemia of Pregnancy
  • Iron Metabolism Disorders
  • Glucose Intolerance
  • Gestational Diabetes

Interventions

DIETARY_SUPPLEMENT

100mg iron fumarate

100mg iron fumarate b.i.d. for 4 consecutive days

DIETARY_SUPPLEMENT

Burgerstein Schwangerschaft & Stillzeit

contains 30 mg iron fumarate, given on 14 consecutive days

Sponsors & Collaborators

  • University Hospital, Zürich

    collaborator OTHER

  • Swiss Federal Institute of Technology

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
OTHER
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
45 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2019-07-03
Primary Completion
2025-12-31
Completion
2025-12-31

Countries

  • Switzerland

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04008147 on ClinicalTrials.gov