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Pathophysiological Characterization of the Neuromuscular Function of a Population With Multiple Comorbidities Suffering From Chronic Renal Failure in Pre-dialysis.

NCT03998917 · Status: WITHDRAWN · Type: OBSERVATIONAL

Last updated 2020-03-25

No results posted yet for this study

Summary

The evolution of chronic kidney disease (CKD) causes a systemic upheaval on the body and a deep fatigue is very often described by patients (50-70% of the patients) even before the start of dialysis (pre-dialysis). This fatigue has many origins, and one of them probably stems from a deterioration of neuromuscular abilities. Very few studies have examined the physiological aspects of neuromuscular fatigue in pre-dialysis patients, and shedding light on potential deficits at this level would allow safe and efficient implementation of adapted physical activity programs.

Our study aims to characterize the pathophysiology of neuromuscular capabilities in chronic advanced renal failure in pre-dialysis patients.

Conditions

  • Chronic Kidney Failure
  • Chronic Kidney Disease stage3
  • Chronic Kidney Disease, Stage 4 (Severe)
  • Chronic Kidney Disease Stage 5
  • Fatigue

Interventions

DIAGNOSTIC_TEST

Discrimination of neuromuscular alterations protocol

Patients will perform a hand grip fatigability test with their dominant hand, followed by a Timed Up and Go Test (TUG-Test), a Five-repetition sit-to-stand-test (5STS-Test) and a10 meters gait speed test.

Sponsors & Collaborators

  • Le Mans Universite

    collaborator OTHER

  • Centre Hospitalier le Mans

    lead OTHER

Principal Investigators

  • Giorgina Piccoli, MD · Centre Hospitalier Le Mans, Nephrology Department

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2019-09-01
Primary Completion
2020-09-01
Completion
2020-12-31

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Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03998917 on ClinicalTrials.gov