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Application of UCAD for Diagnosing Urothelial Carcinoma.

NCT03998371 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 300

Last updated 2019-06-26

No results posted yet for this study

Summary

Chromosomal instability (CIN) refers to ongoing chromosome segregation errors throughout consecutive cell divisions. CIN is a hallmark of human cancer, and it is associated with poor prognosis, metastasis, and therapeutic resistance. Analyzing CIN of the DNA extracted from urothelial cells in urine samples seems a promising method for diagnosing, monitoring, and predicting the prognosis of bladder cancer patients. CIN can be assessed using experimental techniques such as bulk DNA sequencing, fluorescence in situ hybridization (FISH), or conventional karyotyping. However, these techniques are either time-consuming or non-specific. We here intend to study whether a new method named Ultrasensitive Chromosomal Aneuploidy Detection (UCAD), which is based on low-coverage whole-genome sequencing, can be used to analyze CIN thus help diagnosing and treating bladder cancer patients.

Conditions

Interventions

DIAGNOSTIC_TEST

Low-coverage whole-genome sequencing of urine exfoliated cells

The level of CIN The extracted DNA from morning urine will be analyzed by UCAD to determine the level of CIN.

Sponsors & Collaborators

  • Changhai Hospital

    lead OTHER

Principal Investigators

  • Chuangliang Xu, M.D., Ph.D · Changhai Hospital

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2019-05-05
Primary Completion
2020-05-05
Completion
2020-05-05

Countries

  • China

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03998371 on ClinicalTrials.gov