T-cell Responses to Concurrent HIV and Herpesvirus Infections
NCT03996018 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 135
Last updated 2024-11-15
Summary
This is a research study in which we are trying to discover new information about how HIV and herpes viruses interact with the immune system. The goal of the study is to learn more about how T-cells in your immune system respond to and fight off long-term (chronic) viruses, in order to improve medical care in the future.
Conditions
- HIV
- HIV Infections
Interventions
- OTHER
-
T-cell lymphocyte responses
T-cell lymphocyte responses to human immunodeficiency virus (HIV) with and without concomitant herpesvirus infections (specifically, the persistence of HIV-specific human CD8 T-cells in the context of antiretroviral therapy (ART).
Sponsors & Collaborators
-
St. Jude Children's Research Hospital
lead OTHER
Principal Investigators
-
Amanda Green, MD · St. Jude Children's Research Hospital
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2019-06-19
- Primary Completion
- 2023-07-28
- Completion
- 2023-07-28
Countries
- United States
Study Locations
More Related Trials
-
Human Immune Responses Toward HIV-1 Envelope Antigens
NCT01344941 ·Status: COMPLETED
-
Bioclinical Evaluation of 2 Biomarkers of Aviremic HIV-1 in CD4+ T Cells of Adults Undergoing Treatment
NCT03940521 ·Status: ACTIVE_NOT_RECRUITING
-
Safety and Survival of Genetically Modified White Blood Cells in HIV-Infected Persons - A Study in Identical Twin Pairs
NCT00001353 ·Status: COMPLETED
-
Twins Study of Gene Therapy for HIV Infection
NCT00001535 ·Status: COMPLETED ·Phase: PHASE1
-
Safety and Survival of Genetically Modified White Blood Cells in HIV-infected Twins The Gemini Study
NCT04799483 ·Status: ACTIVE_NOT_RECRUITING
-
Immune System Function Following Vaccination in HIV Infected Children Taking Anti-HIV Drugs
NCT00257127 ·Status: COMPLETED ·Phase: NA
-
Immune and Viral Outcomes of HIV-1 Therapy Interruption
NCT00051818 ·Status: COMPLETED ·Phase: PHASE1
-
Impact of a Short-Term Analytical Treatment Interruption and Re-Initiation of Antiretroviral Therapy on Immunologic and Virologic Parameters in HIV-Infected Individuals
NCT03225118 ·Status: COMPLETED
-
Genetically Modified Lymphocytes to Treat HIV-Infected Identical Twins - Study Modifications
NCT00001409 ·Status: COMPLETED ·Phase: PHASE1
-
Resistance to HIV Infection
NCT00069485 ·Status: UNKNOWN
-
A Study of Thymopentin Effects on HIV-1 Infectivity of Blood Mononuclear Cells and Semen in HIV Infected Patients
NCT00002050 ·Status: COMPLETED ·Phase: NA
-
Evaluation of the Safety and Tolerance of Immunotherapy With Autologous, Ex-Vivo Expanded, HIV-Specific Cytotoxic T-Cells in HIV-Infected Patients With CD4+ Counts Between 100-400/mm3
NCT00000756 ·Status: COMPLETED ·Phase: PHASE1
-
Evaluation of HIV-Negative Patients With Low CD4+ T Lymphocyte Counts
NCT00001319 ·Status: COMPLETED
-
Double Blind Study of Thymopentin Effects on HIV-1 Infectivity of Blood Mononuclear Cells and Semen in HIV Infected Patients
NCT00002049 ·Status: COMPLETED ·Phase: NA
-
The Effects of Anti-HIV Therapy on the Immune Systems of Children and Young Adults Infected With HIV
NCT00004735 ·Status: COMPLETED ·Phase: NA
-
Therapeutic Vaccination Followed by Treatment Interruption in HIV Infected Patients
NCT00058734 ·Status: COMPLETED ·Phase: PHASE1
-
Immune Responses in HIV-Positive Patients Receiving an Anti-HIV Drug Combination When Given the HIV Vaccines Remune and vCP1452
NCT00006495 ·Status: COMPLETED ·Phase: PHASE1
-
Double Blind Study of Thymopentin Effects on Patients With HIV-1 Infection
NCT00002051 ·Status: COMPLETED ·Phase: NA
-
Further Evaluation of Thalidomide's Ability to Potentiate the Immune Response to HIV-Infected Patients
NCT00002174 ·Status: COMPLETED ·Phase: NA
-
Evaluation of Safety, Immunogenicity and Efficacy of a Triple Immune Regimen in Adults Initiated on ART During Acute HIV-1
NCT06071767 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
Influenza Vaccine in HIV Infection: Immune Response and Effect on Viral Load
NCT00025922 ·Status: COMPLETED
-
Safety Study of IL-7 in HIV-infected Patients (Inspire)
NCT00477321 ·Status: COMPLETED ·Phase: PHASE1
-
Examining the Role of Genetics in Determining the Immune Response to an HIV Vaccine in HIV-Uninfected Adult Twins
NCT01054872 ·Status: COMPLETED ·Phase: PHASE1
-
Using the Drug Thalidomide to Stimulate T Cells in HIV-Infected People
NCT00053430 ·Status: COMPLETED ·Phase: PHASE2
-
Phase II/III Study Evaluating the Effect of IL-2 on Preservation of the CD4 T-Lymphocytes After Interruption of Antiretroviral Treatment in HIV-Infected Patients With CD4 T-Lymphocyte Count Greater Than 500 Cells/mm3 Who Received Antiretroviral Tx
NCT00071890 ·Status: COMPLETED ·Phase: PHASE2