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Exercise in Patients With a Total Coronary Occlusion

NCT03993522 · Status: TERMINATED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 4

Last updated 2023-01-20

No results posted yet for this study

Summary

A coronary chronic total occlusion refers to the long term complete blockage of a blood vessel supplying the heart.

Exercise is beneficial for patients with heart problems, including people with narrowed blood vessels. However, exercise has not previously been tested in patients with a completely blocked blood vessel. Therefore, the aim of this study is to evaluate exercise testing in participants with a coronary chronic total occlusion, and to see if the physiological changes that occur are reproducible when participants are re-tested. Secondly, the study will see if sustained exercise is safe in this population.

Participants will make 3 visits to our Laboratory. During the first two visits participants will complete symptom limited exercise tests using a stationary bike for approximately 8-12 minutes. The bikes' resistance will gradually increase until participants choose to stop or the researcher ends the test. Participants will wear a mask that collects exhaled breath for testing, and will be connected to an electrocardiogram (heart trace monitor), and blood pressure cuff for monitoring throughout the test. During visits one and three patients will also have blood taken pre and post exercise. Researchers will analyse how the amount of oxygen consumed with increasing exercise relates to the participants' heart rate. A plateau in these measures would indicate a change in the heart's blood supply resulting in reduced function. The participants' third visit will involve cycling under the same conditions as previous visits. However, during this test participants will be asked to cycle continuously for 20 minutes at a resistance set by the researchers. This level of resistance is determined from the results of the first test, as the point at which changes in blood flow and heart function occurred.

In the last five minutes of the test patients will have an echocardiogram (heart scan), to look at the heart function.

Conditions

  • Coronary Occlusion

Interventions

OTHER

Symptom limited cardiopulmonary exercise test & Sub-maximal cardiopulmonary exercise test

Exercise tests on cycle ergometer for the purpose of collecting expired breath gasses

Sponsors & Collaborators

  • Sheffield Hallam University

    collaborator OTHER

  • University of Hull

    lead OTHER

Principal Investigators

  • Angela Hoye, MB, ChB, PhD · Hull York Medical School

Study Design

Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2019-06-01
Primary Completion
2022-12-01
Completion
2022-12-01

Countries

  • United Kingdom

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03993522 on ClinicalTrials.gov