Therapeutic Drug Monitoring of Antiinfectives for Patients With Severe Illness = TAPSI

Summary

Therapeutic drug monitoring of antiinfectives in intensive care patients is an usual research topic of the last years. Based on research result, which have shown subtherapeutic plasma concentrations of antibiotics, a routines therapeutic drug monitoring for β-lactam-antibiotics was implemented in January 2018 at Clinic for Anesthesiology at University Hospital, LMU Munich, Germany. This study is an prospective evaluation of these TDM-program.

Conditions

• Infection, Bacterial

Sponsors & Collaborators

• Ludwig-Maximilians - University of Munich

  lead OTHER

Principal Investigators

• Bruegel Mathias, Dr. med. · Institute of Laboratory Medicine of the University Hospital of Munich

• Liebchen Uwe, Dr.med. · Department of Anaesthesiology of the University Hospital of Munich

• Ines Schroeder, Dr.med. · Department of Anaesthesiology of the University Hospital of Munich

• Paal Michael, Dr.rer.nat. · Institute of Laboratory Medicine of the University Hospital of Munich

• Bernhard Zwissler, Prof.Dr.med. · Department of Anaesthesiology of the University Hospital of Munich

• Daniel Teupser, Prof.Dr.med. · Institute of Laboratory Medicine of the University Hospital of Munich

• Lesca Holdt, Prof.Dr.med. · Institute of Laboratory Medicine of the University Hospital of Munich

• Michael Vogeser, Prof.Dr.med. · Institute of Laboratory Medicine of the University Hospital of Munich

• Eike Speck · Department of Anaesthesiology of the University Hospital of Munich

• Michael Irlbeck, PD.Dr.med. · Department of Anaesthesiology of the University Hospital of Munich

• Thomas Weig, PD.Dr.med. · Department of Anaesthesiology of the University Hospital of Munich

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2018-01-01

Primary Completion

2022-01-01

Completion

2022-01-01

Countries

• Germany

Study Locations