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Impact of Exposure to Persistent Organic Pollutants During Pregnancy on the Composition of Breast Milk and Consequences on the Newborn

NCT03969459 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 88

Last updated 2023-03-22

No results posted yet for this study

Summary

Epidemiological studies link early exposure to persistent organic pollutants (POPs) with health consequences in the newborn. Experimental studies have shown the impact of POPs on the gut microbiota. This project aims to characterize the POPs content in breast milk in an exposed population and to evaluate the impact on breast milk composition and intestinal microbiota establishment in the newborn. The health consequences will be evaluated by the clinical follow-up of the newborn.

Conditions

  • Pesticide
  • Breast Milk
  • Pollution; Exposure
  • Meconium
  • Stool
  • Microbiota
  • Newborn

Interventions

BIOLOGICAL

breast milk collection

3 samples of 20 ml of breast milk will be collected between day 0 and day 4; between day 7 and day 15; and between day 21 and day 30 after childbirth.

BIOLOGICAL

meconium collection

3 samples of 20 ml of meconium milk will be collected between day 0 and day 4; between day 7 and day 15; and between day 21 and day 30 after childbirth.

BIOLOGICAL

newborn feces collection

3 samples of 20 ml of newborn feces will be collected between day 0 and day 4; between day 7 and day 15; and between day 21 and day 30 after childbirth.

OTHER

questionary of pesticide exposure of the mother

maternal questionary of pesticide exposure of the mother

Sponsors & Collaborators

  • Centre Hospitalier Universitaire, Amiens

    lead OTHER

Principal Investigators

  • Andre Leke, MD · CHU Amiens

Eligibility

Min Age
1 Day
Max Age
1 Day
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2019-05-28
Primary Completion
2021-05-28
Completion
2023-02-28

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03969459 on ClinicalTrials.gov