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Volume Support/Assist Control Mode Ventilation and Diaphragmatic Atrophy

NCT03901924 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 468

Last updated 2025-06-06

No results posted yet for this study

Summary

The objective of the study is to determine how controlled mode ventilation and support mode ventilation impact ventilator-free days and diaphragmatic atrophy.

Conditions

  • Mechanical Ventilation Complication

Interventions

OTHER

Volume Support Mode Mechanical Ventilation

This is a spontaneous mode of mechanical ventilation that depends on the patient's efforts. A target volume (6 cc/kg of IBW), PEEP and FiO2 are set by the medical team, and the ventilator varies the inspiratory pressure support with each breath to achieve the target volume. The respiratory rate is fully dependent on the patient. Sedation while on mechanical ventilation will be set at a goal RASS of 0 to -2.

OTHER

Assist Control Mode Mechanical Ventilation

This is a controlled mode of mechanical ventilation that is independent of patient's efforts. A tidal volume (6 cc/kg of IBW), respiratory rate, PEEP and FiO2 are set by the medical team. Sedation while on mechanical ventilation will be set at a goal RASS of 0 to -2.

Sponsors & Collaborators

  • University of Chicago

    lead OTHER

Principal Investigators

  • John P Kress, MD · University of Chicago

  • Bhakti Patel, MD · University of Chicago

  • Roger Struble, MD · University of Iowa

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2019-03-04
Primary Completion
2027-05-31
Completion
2027-05-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03901924 on ClinicalTrials.gov