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The Value of TFF3 in Diagnosis of Gastric Cancer

NCT03894384 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 90

Last updated 2020-01-09

No results posted yet for this study

Summary

Gastric cancer (GC), is a cancer developing from the inner lining of the stomach .The most common cause is infection by the bacterium Helicobacter pylori,which accounts for 60% of cases.

Human pepsinogens (HP) are proenzymes for pepsin; digestive enzymes produced by gastric chief cells, classified into two groups: pepsinogen I (PGI) and pepsinogen II (PGII), humen pepsinogens considered promising serological biomarkers for the screening of atrophic gastritis and gastric cancer.

The trefoil factor family (TFF) of peptides comprises small (12-22kDa) molecules that are secreted by the mammalian gastro-intestinal tract.Trefoil factor family 3 (TFF3) is a more stable non invasive biomarker of gastric cancer risk even in early gastric cancer.

Conditions

Interventions

DIAGNOSTIC_TEST

Trefoil factor family 3 (TFF3),Pepsinogen 1(PG1)

Diagnostic Test: A) CBC . B) FBG. C)KFT. D) LFT. A)CBC: Complete blood count. B)FBG: Fasting blood glucose. C)KFT: Kidney function tests. D)LFT: Liver function tests.

Sponsors & Collaborators

  • Assiut University

    lead OTHER

Principal Investigators

  • Heba Ahmed, MD · Assiut University

  • Ebtesam Farouk, MD · Assiut University

  • Abeer Ahmed, MD · Assiut University

  • Melouk Ahmed, Dr · Assiut University

Eligibility

Min Age
15 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2019-12-01
Primary Completion
2021-11-01
Completion
2022-11-01

Countries

  • Egypt

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03894384 on ClinicalTrials.gov