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The Role of Tumor-associated Macrophages in Colorectal Liver Metastases

NCT03888638 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 101

Last updated 2019-03-25

No results posted yet for this study

Summary

Colorectal cancer is a major cause of mortality worldwide. Most patients develop colorectal liver metastases (CLM), and for such patients hepatectomy combined with chemotherapy may be curative. Nevertheless, in the era of precision medicine there is a critical need of prognostic markers to cope with the heterogeneity of CLM patients. Tumor-associated macrophages (TAMs) pave the way to tissue invasion and intravasation providing a nurturing microenvironment formetastases. The quantification of immune landscape of tumors has provided novel prognostic indicators of cancer progression, and the quantification of TAMs might explain the heterogeneity of CLM patients. Here, we will investigate the development of a new diagnostic tool based on TAMs with the aim to define the causative role of TAMs in CLM patients. This will open new clinical scenarios both for the diagnosis, therapy and prognosis, leading to the refinement of the therapeutic output in a personalized medicine perspective.

Conditions

Interventions

PROCEDURE

Hepatectomy

Removal of a part of the liver because of tumor

Sponsors & Collaborators

  • Humanitas Clinical and Research Center

    lead OTHER

Principal Investigators

  • Matteo Donadon, MD, PhD · Humanitas University

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2015-01-01
Primary Completion
2017-12-31
Completion
2019-03-01

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03888638 on ClinicalTrials.gov