Sleep Related Memory Consolidation in Children With Age Related Focal Epilepsy.

Summary

Age related focal epilepsies in children encompasses, according to the ILAE criteria, benign epilepsy with centro temporal spikes (BECTS), atypical benign partial epilepsy (ABPE) and epileptic encephalopathy with continuous spike and waves during sleep (ECSWS). These non structural epilepsies are associated with interictal sleep spike and waves activated by sleep. Moreover, high prevalence of learning disorders occur in children with age related epilepsies. A correlation is suspected between learning disorders and sleep activation of spike and waves. The investigators suppose that learning dysfunction is linked to loss of information during sleep of epileptic children, unlike for control patients. As sleep allows memory consolidation of words learned during wakefulness, an epileptic activity during sleep may disrupt this consolidation, leading to a loss of information.

Hypothesis: the investigators hypothesize a disruption of memory consolidation after one night in children affected with ABPE and ECSWS (severe group) compared to memory consolidation in children affected with BECTS (benign group), and control group.

Primary purpose:

To demonstrate that the deficit of delayed recall in 15 word learning test after one night is higher for the "severe group", compared to the "benign group" and the control group.

Secondary purposes:

* to study the evolution over time of memory consolidation
* to evaluate the correlation of the deficit of delayed recall with executive dysfunction, clinical factors of epilepsy, neurophysiological factors of epilepsy, and sleep architecture

Conditions

• Benign Epilepsy With Centro Temporal Spikes (BECTS)
• Atypical Benign Partial Epilepsy (ABPE)
• Epileptic Encephalopathy With Continuous Spike and Waves During Sleep (ECSWS)

Interventions

BEHAVIORAL

Neuropsychological testing

memory, executive testing, behaviour questionnaire, visual attention,

BEHAVIORAL

Neuropsychological procedure

Rey auditory verbal learning test, Delayed recall : 1h, 5h, 24h (after one night sleep)

OTHER

Video EEG and polysomnography

Video EEG : 10 electrodes + 3 electrodes for PSG 2h wake EEG Whole night EEG

Sponsors & Collaborators

• University Hospital, Strasbourg, France

  lead OTHER

Principal Investigators

• Anne DE SAINT MARTIN, MD · Hôpitaux Universitaires de Strasbourg

Study Design

Allocation

NON_RANDOMIZED

Purpose

OTHER

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

6 Years

Max Age

13 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2019-03-27

Primary Completion

2027-09-30

Completion

2027-09-30

Countries

• France

Study Locations