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Anti Inflammatory Effects of Local Cryotherapy in Knee Arthritis

NCT03850392 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 47

Last updated 2019-02-21

No results posted yet for this study

Summary

47 patients with non-septic knee arthritis were treated by local ice (30 min) or cold CO2 (2 min) twice at an 8 hour-interval for 1 day.

The synovial fluid was collected just before the first cold application then 24 hours later.

Cytokine, VEGF, NF-kB, PG-E2 levels were assessed in the synovial fluid before/after treatment.

Contralateral arthritic knees were used as paired controls when possible.

Conditions

  • Arthritis Knee
  • Cryotherapy Effect

Interventions

DEVICE

cryotherapy (Thermogel - Artsana or Cryo+ - Cryonic)

cold application (ice 30 min or cold CO2 2 min) twice during 1 day at an 8 hour-interval

Sponsors & Collaborators

  • Centre Hospitalier Universitaire de Besancon

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
SEQUENTIAL

Eligibility

Max Age
85 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2013-02-12
Primary Completion
2017-03-08
Completion
2017-06-22

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03850392 on ClinicalTrials.gov