MedTrace Logo

Whole-Exome Sequencing (WES) of Intraductal Neoplasms of the Bile Duct (IPNB)

NCT03838913 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 60

Last updated 2019-02-12

No results posted yet for this study

Summary

Intraductal papillary neoplasm of the bile duct (IPNB) is a distinct type of biliary tumor characterised with delicate fibrovascular stalks (papillary of villous) covered at biliary epithelium. The typical pathologic feature is dramatical dilation of affected bile ducts due to obstruction by mucin production. IPNB has a better prognosis than bile duct carcinoma, but the current proposed entity contains multiple definitions or categories, thus confused in pathology.

Although mutations of several genes on IPNBs (such as GNAS, KRAS, APC, CTNNB1, and RNF43) identified in previous studies, there is still an unification at gene expression signature.

This research trial will use whole exome sequencing and subsequent bioinformatic analysis in finding causative mutations in deoxyribonucleic acid (DNA) samples from IPNBs patients.

Conditions

  • Bile Duct Neoplasms
  • Intraductal Papillary Mucinous Neoplasm

Sponsors & Collaborators

  • Fujian Medical University Union Hospital

    collaborator OTHER

  • First Affiliated Hospital of Fujian Medical University

    collaborator OTHER

  • Fujian Provincial Hospital

    lead OTHER

Principal Investigators

  • Yaodong Wang, Prof · Fujian Provincial Hospital

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2019-02-15
Primary Completion
2019-06-30
Completion
2019-12-31

Countries

  • China

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03838913 on ClinicalTrials.gov