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Molecular and Structural Comparison of Hypospadic and Normal Children Prepuces

NCT03838458 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 52

Last updated 2020-04-28

No results posted yet for this study

Summary

The aim of this study is to compare prepuce tissue samples from healthy male children who applied for circumcision and children with isolated hypospadias. Estrogen receptor 1 (ER1), androgen receptor (AR), FGFR2, transforming growth factor beta (TGF beta) and HOXA13 gene expression in the prepuce is planned to investigate via polymerase chain reaction (PCR) method. Mucosal vascular and nerve densities, and extracellular matrix density of laminin and collagen protein is planned to investigate via immunohistochemical examination.

Conditions

  • Hypospadias

Sponsors & Collaborators

  • Trakya University

    lead OTHER

Principal Investigators

  • Dincer Avlan, Profesor, MD · Trakya University Faculty of Medicine, Pediatric Surgery Department

Eligibility

Max Age
18 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2019-01-07
Primary Completion
2020-01-07
Completion
2020-03-10

Countries

  • Turkey (Türkiye)

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03838458 on ClinicalTrials.gov