Dynamics of 18-FDG Uptake in Stage III/IV Non Small Cell Lung Cancer During First Line Pembrolizumab Treatment
NCT03832348 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 40
Last updated 2026-01-02
Summary
The aim of this study is to describe the early dynamics of 18-FDG uptake in non smal cell lung cancer during first line treatment with pembrolizumab, and to evaluate whether or not they differ according to treatment response at 3 months.
Conditions
- Non Small Cell Lung Cancer
Interventions
- DEVICE
-
PET scan imaging
3 PET scans will be performed after each 3 first infusions of Pembrolizumab
Sponsors & Collaborators
-
Centre Henri Becquerel
lead OTHER
Principal Investigators
-
Stephanie Becker, MD · Centre Henri Becquerel
-
Florian Guisier, MD · CHU Rouen
Study Design
- Allocation
- NA
- Purpose
- OTHER
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2019-06-17
- Primary Completion
- 2024-06-03
- Completion
- 2024-07-03
Countries
- France
Study Locations
More Related Trials
-
Inflammation, Cachexia and Therapeutic Response in Lung Cancer Treated With Immune Checkpoint Inhibitors: Exploratory Observational Study
NCT07004868 ·Status: RECRUITING
-
Pembrolizumab in Elderly Patients With Advanced Lung Cancer
NCT03293680 ·Status: COMPLETED ·Phase: PHASE2
-
89Zr-labeled Pembrolizumab in Patients With Non-small-cell Lung Cancer
NCT03065764 ·Status: UNKNOWN ·Phase: PHASE2
-
18F-PD-L1 PET/CT in Nivolumab Treated Patients With NSCLC
NCT03564197 ·Status: COMPLETED ·Phase: NA
-
Study of Pembrolizumab (MK-3475) Versus Platinum-Based Chemotherapy for Participants With Programmed Cell Death-Ligand 1 (PD-L1)-Positive Advanced or Metastatic Non-Small Cell Lung Cancer (MK-3475-042/KEYNOTE-042)
NCT02220894 ·Status: COMPLETED ·Phase: PHASE3
-
Study of Pembrolizumab (MK-3475) in Participants With Advanced Non-small Cell Lung Cancer (MK-3475-025/KEYNOTE-025)
NCT02007070 ·Status: COMPLETED ·Phase: PHASE1
-
Efficacy and Safety of PEMbrolizumab PD-L1-positive (>50% of Tumor Cells), Advanced NSCL Cancer(PEMBREIZH)
NCT05321212 ·Status: COMPLETED
-
Association Between Circulating Immune Cells and the Tumor Immune Contexture in Resectable Non-small Cell Lung Cancer
NCT02551211 ·Status: TERMINATED ·Phase: NA
-
Pembrolizumab (MK-3475) as Maintainance in Treated Patients With Unresectable Stage III NSCLC
NCT03379441 ·Status: UNKNOWN ·Phase: PHASE2
-
Prospective Study to Evaluate the Blood Kinetics of Immune Cells and Immunosuppressive Cytokines After Exposure to an Immunity Checkpoint Inhibitor (ICI): Study of the Impact of Chemotherapy
NCT04487457 ·Status: COMPLETED
-
Study of LYC-55716 With Pembrolizumab in Adult Subjects With Non-Small Cell Lung Cancer
NCT03396497 ·Status: UNKNOWN ·Phase: PHASE1
-
Radiomic Signature as Predictive Marker of Response to Chemoradiation and Durvalumab in Stage III NSCLC.
NCT04364776 ·Status: UNKNOWN
-
PD-L1 Inhibitor Rechallenge After PD-1 Immunotherapy for Patients With Solid Tumor Beyond Lung Cancer
NCT05325684 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
Double Immune Checkpoint Inhibitors in PD-L1-positive Stage IV Non-small Lung CancEr
NCT03469960 ·Status: COMPLETED ·Phase: PHASE3
-
Early Prediction of Therapeutic Response to Targeted Therapy in Stage IIIB/IV or Recurrent Lung Cancer Patients
NCT00708448 ·Status: COMPLETED ·Phase: PHASE1
-
Pembrolizumab in Combination With Radiotherapy in Locally Advanced Non-Small Cell Lung Cancer (NSCLC)
NCT03245177 ·Status: WITHDRAWN ·Phase: PHASE1
-
Observational Retro-prospective Study on PD1/PDL1 Inhibitors Treatment Duration in Patients With NSCLC
NCT05418660 ·Status: UNKNOWN
-
Study of Pembrolizumab (MK-3475) Compared to Platinum-Based Chemotherapies in Participants With Metastatic Non-Small Cell Lung Cancer (MK-3475-024/KEYNOTE-024)
NCT02142738 ·Status: COMPLETED ·Phase: PHASE3
-
Pembrolizumab + Platinum Doublets Without Radiation for Programmed Death-ligand 1 (PD-L1) ≥50% Locally Advanced NSCLC
NCT04153734 ·Status: NOT_YET_RECRUITING ·Phase: PHASE2
-
Precision Immuno-Oncology for Advanced Non-small Cell Lung Cancer Patients With PD-1 ICI Resistance
NCT03833440 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
Pembrolizumab + Imprime PGG for Metastatic Non-small Cell Lung Cancer After Progression on First-Line Therapy: Big Ten Cancer Research Consortium BTCRC-LUN15-017
NCT03003468 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Study of Pembrolizumab Given With Ipilimumab or Placebo in Participants With Untreated Metastatic Non-Small Cell Lung Cancer (NSCLC) (MK-3475-598/KEYNOTE-598)
NCT03302234 ·Status: COMPLETED ·Phase: PHASE3
-
Pembrolizumab and Palliative Radiotherapy in Lung
NCT02587455 ·Status: COMPLETED ·Phase: PHASE1
-
Study of Pembrolizumab With Maintenance Olaparib or Maintenance Pemetrexed in First-line (1L) Metastatic Nonsquamous Non-Small-Cell Lung Cancer (NSCLC) (MK-7339-006, KEYLYNK-006)
NCT03976323 ·Status: COMPLETED ·Phase: PHASE3
-
Pembrolizumab in Combination With Plinabulin and Docetaxel For Metastatic NSCLC After ICIs (KeyPemls-004)
NCT05599789 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2