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Efficacy of Nitrous Oxide in OCD: Pilot Study

NCT03826693 · Status: RECRUITING · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 45

Last updated 2025-08-27

No results posted yet for this study

Summary

This study investigates whether the commonly used and well-tolerated inhaled anesthetic nitrous oxide can rapidly improve symptoms of OCD.

Conditions

  • Obsessive-Compulsive Disorder

Interventions

DRUG

Nitrous Oxide

OCD participants in this arm will receive 50%oxygen/50% nitrous oxide admixture for 60 minutes.

DRUG

Nitrogen

OCD participants in this arm will receive 50%oxygen/50% nitrogen admixture for 60 minutes.

Sponsors & Collaborators

Principal Investigators

  • Peter J van Roessel, MD, PhD · Stanford Univeristy

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-04-17
Primary Completion
2026-09-30
Completion
2027-10-31
FDA Drug
Yes

Countries

  • United States

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03826693 on ClinicalTrials.gov