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Immediate ART in Subjects With Opportunistic Diseases

NCT03825523 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 114

Last updated 2026-06-30

No results posted yet for this study

Summary

The aim of this study is to compare the clinical response and mortality rate due to opportunistic disease in HIV-infected individuals who start immediate versus conventional antiretroviral therapy (ART).

Immediate ART (iART) is defined as starting antiretroviral therapy within the first 48 hours after hospitalization. Conventional ART (cART) is defined as starting antiretroviral therapy once the opportunistic infection is under control at the discretion of the infectious disease specialist.

Conditions

Interventions

DRUG

Antiretroviral Therapy (ART)

Immediate initiation of ART within 48 hours of hospital admission.

DRUG

Antiretroviral Therapy (ART)

Deferred initiation of ART, with timing determined by the treating physician based on clinical stability and control of the opportunistic infection.

Sponsors & Collaborators

  • Gustavo Reyes-Teran

    lead OTHER_GOV

Principal Investigators

  • Amy B. Peralta-Prado, M.D. · Instituto Nacional de Enfermedades Respiratorias

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2018-01-29
Primary Completion
2025-08-05
Completion
2025-08-05

Countries

  • Mexico

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03825523 on ClinicalTrials.gov