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GnRH Agonist Versus hCG Trigger in Ovulation Induction With Intrauterine Insemination.

NCT03825445 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 197

Last updated 2019-01-31

No results posted yet for this study

Summary

This study aims to compare clinical pregnancy rates (CPR) in patients who are administered either Gonadotropin-releasing hormone agonists (GnRHa) or human chorionic gonadotropin (hCG) for ovulation trigger in intrauterine insemination (IUI) cycles. A prospective randomized comparative study was conducted at Hue University Hospital in Vietnam. Total of 197 infertile women were randomly assigned to receive either GnRHa trigger (n=98 cycles) or hCG trigger (n= 99 cycles) for ovulation trigger. Patients returned for ultrasound monitoring 24 hours after IUI to confirm ovulation. A clinical pregnancy was defined as the presence of gestational sac with fetal cardiac activity.

Conditions

  • Ovulation Induction

Interventions

DRUG

GnRHa (Fertipeptil 0.1mg)

Two doses of GnRH-a (Fertipeptil 0.1mg x 2 vial) for ovulation trigger after ovarian stimulation for IUI.

DRUG

hCG (Pregnyl 5000IU)

hCG (Pregnyl 5000IU) for ovulation trigger after ovarian stimulation for IUI.

Sponsors & Collaborators

  • Hue University of Medicine and Pharmacy

    lead OTHER

Principal Investigators

  • Minh Tam Le, Prof.MD.PhD · Hue University of Medicine and Pharmacy, Hue University

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
45 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2016-04-01
Primary Completion
2017-06-30
Completion
2017-06-30

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03825445 on ClinicalTrials.gov