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Clinical Significance of Occult Central Nervous System Disease In Adult Acute Lymphoblastic Leukemia

NCT03803670 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 241

Last updated 2019-01-16

No results posted yet for this study

Summary

Central nervous system involvement at diagnosis remains an obstacle to a long-term cure of patients affected by acute lymphoblastic leukemia. The investigators have previously reported that flow cytometry (FCM) is better than conventional cytology (CC) in demonstrating the presence of leukemic cells in the patients'(pts) cerebrospinal fluid (CSF), especially in samples with low cell counts. In the framework of the national Campus ALL program aimed at improving the management of adult ALL patients in the context of the GIMEMA protocols, in the present study the investigators retrospectively evaluated the incidence of occult CNS positivity and its impact on outcome in 241 adult pts with newly diagnosed ALL from 13 centers.

Conditions

Interventions

DIAGNOSTIC_TEST

evaluation of cerebrospinal fluid of ALL

We evaluated cerebrospinal fluids of patients with ALL by conventional cytology and by flow cytometry

Sponsors & Collaborators

  • University of Rome Tor Vergata

    lead OTHER

Principal Investigators

  • Maria Ilaria Del Principe, MD · University Tor Vergata of Rome

Eligibility

Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2007-01-01
Primary Completion
2019-01-01
Completion
2019-01-10

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03803670 on ClinicalTrials.gov