Pemetrexed Plus Apatinib Maintenance Treatment in Patients With Non-squamous Non-small Cell Lung Cancer Patients Who Have Not Progressed After 4 Cycles of Induction Chemotherapy of Pemetrexed in Combination With Platinum-based Regimen
NCT03792503 · Status: WITHDRAWN · Phase: PHASE4 · Type: INTERVENTIONAL
Last updated 2024-02-28
Summary
In order to further improve the therapeutic efficacy of advanced no-squamous non-small cell lung cancer patients, improve the life cycle, this study will take the standard after treatment pemetrexed combined other anti-angiogenesis drugs to maintain as the direction, so as to provide more over the evidence for the treatment of advanced NSCLC.
Conditions
- Advanced Non-squamous Non-small-cell Lung Cancer
Interventions
- DRUG
-
Apatinib
Apatinib 500 mg Po qd
- DRUG
-
Pemetrexed
Pemetrexe 500 mg/m2 d1×q3w
Sponsors & Collaborators
-
Xinqiao Hospital of Chongqing
lead OTHER
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2019-02-28
- Primary Completion
- 2020-02-29
- Completion
- 2022-02-28
Countries
- China
Study Locations
More Related Trials
-
A Study Comparing of Two Different Chemotherapy Regimens, in Patients With Advanced Non-Squamous Non-Small Cell Lung Cancer
NCT00606021 ·Status: COMPLETED ·Phase: PHASE2
-
Camrelizumab Combined With Apatinib Mesylate and Standard Chemotherapy (Pemetrixed + Carboplatin) in Patients With Tyrosine Kinase Inhibitor Failure in ALK-positive Advanced NSCLC
NCT04425135 ·Status: UNKNOWN ·Phase: PHASE2
-
Ph II Trial of Carboplatin and Pemetrexed With or Without AZD1775 for Untreated Lung Cancer
NCT02087241 ·Status: TERMINATED ·Phase: PHASE2
-
Pemetrexed and Best Supportive Care Versus Placebo and Best Supportive Care in Non-Small Cell Lung Cancer (NSCLC)
NCT00102804 ·Status: COMPLETED ·Phase: PHASE3
-
A Prospective, Single-center, One-arm Clinical Study of Apatinib Combined With Chemotherapy for Pretreated Patients With Advanced Small Cell Lung Cancer
NCT03547804 ·Status: COMPLETED ·Phase: PHASE2
-
Gene Expression Levels in Predicting Treatment Response in Patients With Stage IV Non-small Cell Lung Cancer
NCT02145078 ·Status: TERMINATED ·Phase: NA
-
Chemotherapy for Patients With Non-Small Cell Lung Cancer
NCT00380718 ·Status: COMPLETED ·Phase: PHASE4
-
A Study of Apatinib Plus Docetaxel for Treatment of Advanced Non-squamous Non-small Cell Lung Cancer With Bone Metastases
NCT03127319 ·Status: UNKNOWN ·Phase: PHASE2
-
Chemotherapy for Patients With Non-Small Cell Lung Cancer (NSCLC)
NCT00391274 ·Status: COMPLETED ·Phase: PHASE3
-
Pemetrexed in Advanced Non-Small-Cell Lung Cancer: at Progression vs Maintenance Therapy After Induction Chemotherapy
NCT02004184 ·Status: TERMINATED ·Phase: PHASE3
-
A Efficacy and Safety Study of Anlotinib Hydrochloride Capsule Combined With Chemotherapy Versus Placebo Combined With Chemotherapy as First-line Treatment in Subjects With Advanced Non-squamous Cell Non-small Cell Lung Cancer
NCT04439890 ·Status: UNKNOWN ·Phase: PHASE3
-
Chemotherapy for Patients With Non-Small Cell Lung Cancer Who Are Non-Smokers
NCT00409006 ·Status: COMPLETED ·Phase: PHASE2
-
Trial of Pemetrexed With or Without PF-3512676 in Advanced Non-Small Cell Lung Cancer
NCT00321308 ·Status: TERMINATED ·Phase: PHASE2
-
A Study of Bevacizumab, Carboplatin, and Paclitaxel or Pemetrexed With or Without Atezolizumab in Chemotherapy-Naïve Patients With Stage IV Non-Squamous Non-Small Cell Lung Cancer (IMpower151)
NCT04194203 ·Status: COMPLETED ·Phase: PHASE3
-
Dosage Schedule Study of Pemetrexed Monochemotherapy for Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC)
NCT00370292 ·Status: COMPLETED ·Phase: PHASE2
-
Study of Pemetrexed+Platinum Chemotherapy With or Without Pembrolizumab (MK-3475) in Participants With First Line Metastatic Nonsquamous Non-small Cell Lung Cancer (MK-3475-189/KEYNOTE-189)
NCT02578680 ·Status: COMPLETED ·Phase: PHASE3
-
A Study of Pemetrexed Plus Cisplatin With Concurrent Radiation Therapy Followed by Docetaxel Consolidation in Patients With Inoperable Squamous Cell Lung Cancer
NCT02787473 ·Status: UNKNOWN ·Phase: PHASE2
-
Pyrotinib Combined With Pemetrexed Plus Carboplatin in the First-line Treatment
NCT04706949 ·Status: UNKNOWN ·Phase: PHASE2
-
Pemetrexed-free vs. Pemetrexed-based Immunochemotherapy in Metastatic TTF-1 Negative Lung Adenocarcinoma
NCT05689671 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE4
-
Pemetrexed and LBH589 in Patients With Advanced Non-Small Cell Lung Cancer
NCT00907179 ·Status: TERMINATED ·Phase: PHASE1
-
Study of Pazopanib and Pemetrexed in Advanced Non-small Cell Lung Cancer
NCT00871403 ·Status: COMPLETED ·Phase: PHASE2
-
Chemotherapy and Radiation in Treating Participants With Stage 3 Non-Small Cell Lung Cancer
NCT00686959 ·Status: COMPLETED ·Phase: PHASE3
-
A Study of Induction and Maintenance Treatment of Advanced or Metastatic Non Squamous Non-Small Cell Lung Cancer
NCT00867009 ·Status: COMPLETED ·Phase: PHASE2
-
Carboplatin Plus Pemetrexed Plus Atezolizumab Plus Bevacizumab in Chemotherapy and Immunotherapy-naïve Patients With Stage IV Non-squamous Non-small Cell Lung Cancer
NCT03713944 ·Status: TERMINATED ·Phase: PHASE2
-
Platinum Doublet Chemotherapy and Proton Beam Radiation Therapy in Treating Patients With Stage II-III Non-small Cell Lung Cancer That Cannot Be Removed by Surgery
NCT03132532 ·Status: COMPLETED ·Phase: PHASE2