Efficacy and Safety of Maintenance Apatinib Combined With Pemetrexed in Advanced Non-squamous Non-small Cell Lung Cancer Patients
NCT03190239 · Status: WITHDRAWN · Phase: PHASE2 · Type: INTERVENTIONAL
Last updated 2024-02-28
Summary
Lung cancer is a malignant tumor that causes the highest morbidity and mortality, and the main pathological type is non-small cell lung cancer (NSCLC). Most of them present with advanced stage at diagnosis. This design is to study maintenance therapy with pemetrexed plus apatinib after first line induction therapy four cycles for advanced non-squamous non-small-cell lung cancer. XQonc-0007
Conditions
- Advanced Non-squamous Non-small-cell Lung Cancer
Interventions
- DRUG
-
Apatinib
Apatinib 250mg qd
- DRUG
-
Pemetrexed
Pemetrexed 500mg/m2 qm
Sponsors & Collaborators
-
Xinqiao Hospital of Chongqing
lead OTHER
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 18 Years
- Max Age
- 75 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2017-07-15
- Primary Completion
- 2020-07-30
- Completion
- 2020-07-30
Countries
- China
Study Locations
More Related Trials
-
Apatinib and Etoposide as the Maintenance Therapy in Extensive-stage Small Cell Lung Cancer After First-line Chemotherapy
NCT03135977 ·Status: UNKNOWN ·Phase: PHASE2
-
A Efficacy and Safety Study of Anlotinib Hydrochloride Capsule Combined With Chemotherapy Versus Placebo Combined With Chemotherapy as First-line Treatment in Subjects With Advanced Non-squamous Cell Non-small Cell Lung Cancer
NCT04439890 ·Status: UNKNOWN ·Phase: PHASE3
-
A Study of Apatinib Plus Docetaxel for Treatment of Advanced Non-squamous Non-small Cell Lung Cancer With Bone Metastases
NCT03127319 ·Status: UNKNOWN ·Phase: PHASE2
-
Camrelizumab Combined With Apatinib Mesylate and Standard Chemotherapy (Pemetrixed + Carboplatin) in Patients With Tyrosine Kinase Inhibitor Failure in ALK-positive Advanced NSCLC
NCT04425135 ·Status: UNKNOWN ·Phase: PHASE2
-
A Study of Bevacizumab, Carboplatin, and Paclitaxel or Pemetrexed With or Without Atezolizumab in Chemotherapy-Naïve Patients With Stage IV Non-Squamous Non-Small Cell Lung Cancer (IMpower151)
NCT04194203 ·Status: COMPLETED ·Phase: PHASE3
-
Apatinib for Extensive Stage Small Cell Lung Cancer After Second/Third Line Chemotherapy.
NCT02945852 ·Status: COMPLETED ·Phase: PHASE2
-
Efficacy and Safety of First-line Anti-PD-1/PD-L1 Monoclonal Antibody in Combination With Chemotherapy and Bronchoscopy-assisted Interventional Therapy in Patients With Advanced Central Non-small Cell Lung Cancer
NCT04702009 ·Status: COMPLETED ·Phase: PHASE2/PHASE3
-
Pemetrexed in Advanced Non-Small-Cell Lung Cancer: at Progression vs Maintenance Therapy After Induction Chemotherapy
NCT02004184 ·Status: TERMINATED ·Phase: PHASE3
-
Apatinib as the Maintenance Therapy for Extensive Stage Small Cell Lung Cancer After Combined With Etoposide/Cisplatin
NCT02875457 ·Status: UNKNOWN ·Phase: PHASE3
-
PD-L1 Inhibitor Combined With Apatinib as First-line Maintenance Treatment for Extensive-stage Small Cell Lung Cancer
NCT06429696 ·Status: RECRUITING ·Phase: PHASE2
-
Pemetrexed-free vs. Pemetrexed-based Immunochemotherapy in Metastatic TTF-1 Negative Lung Adenocarcinoma
NCT05689671 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE4
-
Paclitaxel Detection in NSCLC Treated With TC Regimen
NCT02737709 ·Status: TERMINATED ·Phase: PHASE2
-
Neoadjuvant Chemo for Non-metastatic Non-small Cell Lung Cancer
NCT01860040 ·Status: TERMINATED ·Phase: PHASE2
-
Application of Pablizumab Combined With Apatinib and Chemotherapy in Resectable Non-small Cell Lung Cancer: A Prospective, Single Arm, Single Center Phase II Clinical Study of Neoadjuvant Therapy
NCT04968002 ·Status: UNKNOWN ·Phase: PHASE2/PHASE3
-
A Study in Non-squamous Non Small Cell Lung Cancer in Asian Patients
NCT01020786 ·Status: COMPLETED ·Phase: PHASE4
-
A Study Comparing of Two Different Chemotherapy Regimens, in Patients With Advanced Non-Squamous Non-Small Cell Lung Cancer
NCT00606021 ·Status: COMPLETED ·Phase: PHASE2
-
Pemetrexed and Best Supportive Care Versus Placebo and Best Supportive Care in Non-Small Cell Lung Cancer (NSCLC)
NCT00102804 ·Status: COMPLETED ·Phase: PHASE3
-
Chemotherapy for Patients With Non-Small Cell Lung Cancer (NSCLC)
NCT00391274 ·Status: COMPLETED ·Phase: PHASE3
-
Assess Safety & Efficacy of Selumetinib When Given in Combination With Standard First Line Treatment for Advanced Non-small Cell Lung Cancer
NCT01809210 ·Status: COMPLETED ·Phase: PHASE1
-
Chemotherapy for Patients With Non-Small Cell Lung Cancer Who Are Non-Smokers
NCT00409006 ·Status: COMPLETED ·Phase: PHASE2
-
A Global Phase III Study of Rilvegostomig or Pembrolizumab Plus Chemotherapy for First-Line Treatment of Metastatic Squamous Non-small Cell Lung Cancer (NSCLC)
NCT06692738 ·Status: RECRUITING ·Phase: PHASE3
-
A Platform Study in Non-Small Cell Lung Cancer (NSCLC)
NCT06996782 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
A Single-arm, Multicenter, Prospective Clinical Study of Adebrelimab Combined With Apatinib Neoadjuvant Therapy for Resectable Non-small Cell Lung Cancer
NCT07031154 ·Status: NOT_YET_RECRUITING ·Phase: PHASE2
-
A Study of Induction and Maintenance Treatment of Advanced or Metastatic Non Squamous Non-Small Cell Lung Cancer
NCT00867009 ·Status: COMPLETED ·Phase: PHASE2
-
Concurrent Proton and Chemotherapy in Locally Advanced Stage IIIA/B Non-Small Cell Lung Cancer (NSCLC)
NCT00495170 ·Status: COMPLETED ·Phase: PHASE2