Danish Trial of Beta Blocker Treatment After Myocardial Infarction Without Reduced Ejection Fraction

Summary

To determine whether long-term treatment with oral betablocker therapy after myocardial infarction in patient with no heart failure reduces the composite outcome of recurrent MI, all-cause mortality, revascularisation with percutaneous coronary intervention or coronary artery bypass graft, ischemic stroke, incident heart failure, or malignant ventricular arrhythmia including resuscitated cardiac arrest of cardiac origin.

Conditions

• Acute Myocardial Infarction
• Non-ST Elevation Myocardial Infarction (nSTEMI)
• ST Elevation Myocardial Infarction

Interventions

DRUG

Metoprolol Succinate

Eligible patients randomized to receive long-term therapy with oral beta-blockade

DRUG

Bisoprolol

Eligible patients randomized to receive long-term therapy with oral beta-blockade

DRUG

Carvedilol

Eligible patients randomized to receive long-term therapy with oral beta-blockade

DRUG

Nebivolol

Eligible patients randomized to receive long-term therapy with oral beta-blockade

Sponsors & Collaborators

• Amager Hospital

  collaborator OTHER

• University Hospital Bispebjerg and Frederiksberg

  collaborator OTHER

• Bornholm Hospital

  collaborator UNKNOWN

• Gentofte Hospital

  collaborator UNKNOWN

• Glostrup University Hospital, Copenhagen

  collaborator OTHER

• Herlev Hospital

  collaborator OTHER

• Hvidovre University Hospital

  collaborator OTHER

• Nordsjaellands Hospital

  collaborator OTHER

• Holbaek Hospital

  collaborator UNKNOWN

• Nykoebing Hospital

  collaborator UNKNOWN

• Naestved Hospital

  collaborator OTHER

• Zealand University Hospital

  collaborator OTHER

• Slagelse Hospital

  collaborator OTHER

• Odense University Hospital

  collaborator OTHER

• Svendborg Hospital

  collaborator OTHER

• Sydvestjysk Sygehus

  collaborator UNKNOWN

• Hospital of Southern Jutland

  collaborator OTHER

• Sygehus Lillebaelt (Vejle and Kolding)

  collaborator UNKNOWN

• Aarhus University Hospital

  collaborator OTHER

• Hospitalsenheden Midt

  collaborator UNKNOWN

• Hospitalsenheden Vest

  collaborator OTHER

• Regionshospitalet Horsens

  collaborator OTHER

• Silkeborg Sygehus

  collaborator UNKNOWN

• Aalborg University Hospital

  collaborator OTHER

• Bispebjerg Hospital

  lead OTHER

Principal Investigators

• Eva IB Prescott, MD, DMsC · Bispebjerg Frederiksberg University Hospital

• Anna Meta D Kristensen, MD · University Hospital Bispebjerg and Frederiksberg

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2018-12-17

Primary Completion

2025-04-01

Completion

2035-12-10

Countries

• Denmark

Study Locations