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Cerebral Perfusion During Induction of General Anesthesia

NCT03769142 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 100

Last updated 2018-12-07

No results posted yet for this study

Summary

Arterial hypotension during general anesthesia remains a factor of poor outcomes, increases the risk of myocardial infarction, acute kidney injury and 1-year mortality. Furthermore, arterial hypotension may also decrease cerebral perfusion contributing to worsen neurological outcome. It seems necessary to monitor cerebral perfusion during anesthesia and to define individual dynamic targets of blood pressure. The goal of this study is to evaluate cerebral perfusion change in adult patients with or without cardiovascular risk factors during a standardized propofol-remifentanil anesthesia induction. Cerebral perfusion will be evaluated and compared using the simultaneously measure of TCD, NIRS and BIS. Those measures will be also repeated during and after treatment of arterial hypotension episodes in both groups.

Conditions

  • Radiography
  • Interventional

Interventions

PROCEDURE

All monitoring

All monitoring (TCD, BIS, NIRS) are collected from the healthy side, contralateral to the interventional side

Sponsors & Collaborators

  • INSERM UMR-942, Paris, France

    collaborator OTHER

  • Department of Anesthesiology, Hopital Foch, Suresnes, France.

    collaborator UNKNOWN

  • M3DISIM

    collaborator OTHER

  • Ouctomes Research Consortium, Cleveland Clinic, Ohio, USA

    collaborator UNKNOWN

  • Assistance Publique - Hôpitaux de Paris

    lead OTHER

Principal Investigators

  • Joaquim MATEO, MD · Assistance Publique - Hôpitaux de Paris

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2014-02-01
Primary Completion
2016-12-01
Completion
2016-12-01

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03769142 on ClinicalTrials.gov