MedTrace Logo

Finding the Latent Treponema Pallidum

NCT03754517 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 30

Last updated 2019-03-28

No results posted yet for this study

Summary

Some syphilitic patients remain in a serologically positive state after the recommended therapy. Whether a serofast state could represent a persistent low-level infection by Treponema pallidum is still unknown. The possibility that persistent nontreponemal antibodies after treatment represent persistence of Treponema pallidum was raised by some investigators. The investigators use the Next-Generation Sequencing to test blood plasma, srum, cerebrospinal fluid, aqueous humor, lymph nodes, skin lesion, saliva, semen,milk of serofast patient and other positive and negative controls.

Conditions

  • Syphilis

Interventions

DIAGNOSTIC_TEST

RPR Titer

RPR titer; TPPA/FTA-ABS; Next-Generation Sequencing

Sponsors & Collaborators

  • Peking Union Medical College Hospital

    lead OTHER

Principal Investigators

  • Jun Li · Peking Union Medical College Hospital

Eligibility

Min Age
18 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2016-08-31
Primary Completion
2019-11-30
Completion
2019-12-31

Countries

  • China

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03754517 on ClinicalTrials.gov