Microarchitecture, Bone Strength and Fracture Risk in Long-term Type 1 Diabetes

Summary

This single center case control study will assess differences in bone structure between women and men with longstanding type 1 diabetes (diabetes duration\>/= 25 years) and healthy controls.

Conditions

• Type 1 Diabetes Mellitus

Interventions

DIAGNOSTIC_TEST

Biochemical Tests

The investigators will perform blood tests in every participant.

DIAGNOSTIC_TEST

Osteodensitometry

The investigators will perform an osteodensitometry in every participant.

DIAGNOSTIC_TEST

Clinical Tests

The investigators perform the following clinical tests: vibration threshold test, monofilament test, chair rise test and timed up and go test in every participant.

DIAGNOSTIC_TEST

HR-QCT

The investigators will perform HR-QCT measurements of the proximal femur and tibia in every participant.

DIAGNOSTIC_TEST

HR-pQCT

The investigators will perform HR-pQCT measurements of the distal radius and distal tibia in every participant.

Sponsors & Collaborators

• Insel Gruppe AG, University Hospital Bern

  collaborator OTHER

• University Hospital Schleswig-Holstein

  collaborator OTHER

• University Hospital, Basel, Switzerland

  collaborator OTHER

• Christian Meier

  lead OTHER

Principal Investigators

• Christian Meier, Prof. · University Hospital, Basel, Switzerland

Study Design

Allocation

NA

Purpose

DIAGNOSTIC

Masking

NONE

Model

SINGLE_GROUP

Eligibility

Min Age

40 Years

Max Age

80 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2018-10-01

Primary Completion

2021-07-01

Completion

2021-07-01

Countries

• Switzerland

Study Locations