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Hypothermia After Cardiac Arrest - Effects on Myocardial Function and Inflammatory Response.

NCT03743584 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 26

Last updated 2021-09-20

No results posted yet for this study

Summary

The on-going randomized clinical trial TTM2 (Target Hypothermia Versus Targeted Normothermia After Out-of-hospital Cardiac Arrest, NCT02908308) investigates if there is a difference in mortality, neurological function or quality of life in comatose survivors after out-of-hospital cardiac arrest if treated (Group A) at target temperature of 33 oC or (Group B) by avoiding fever during the first 24 h.

In this sub study, the effect of different target temperatures on cardiac and circulatory physiology is evaluated by echocardiography and pulmonary artery catheter. Tissue damage after cardiac arrest in part is caused by an activation of different parts of the inflammatory system (reperfusion injury). This study investigates the effect of temperature management on inflammation and the link to the circulatory effects.

Conditions

  • Out of Hospital Cardiac Arrest
  • Inflammatory Response
  • Ischemia Reperfusion Injury
  • Hypothermia

Interventions

PROCEDURE

Targeted temperature management

Target temperature management at 33°C

PROCEDURE

Standard care, early treatment of fever

Standard of care with early treatment of fever

Sponsors & Collaborators

  • Oslo University Hospital

    lead OTHER

Principal Investigators

  • Søren Pischke, MD, PhD · Oslo University Hospital, Oslo, Norway

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2018-11-08
Primary Completion
2020-07-20
Completion
2020-07-20

Countries

  • Norway

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03743584 on ClinicalTrials.gov