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Endobronchial Ultrasound Guided Interstitial Photodynamic Therapy in Treating Patients With Locally Advanced Lung Cancer

NCT03735095 · Status: COMPLETED · Phase: PHASE1/PHASE2 · Type: INTERVENTIONAL · Enrollment: 19

Last updated 2026-05-14

Study results available
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Summary

This Phase I/Il studies the side effects of endobronchial ultrasound guided interstitial photodynamic therapy work in treating patients with lung cancer that has spread to nearby tissues or lymph nodes. Photodynamic therapy consists of injecting a light sensitive drug called a photosensitizer, such as porfimer sodium, into the vein, waiting for it to accumulate in the tumor, and then activating it with a red laser light. Giving photodynamic therapy with Porfimer sodium may reduce the tumor size in patients with lung cancer.

Conditions

  • Locally Advanced Lung Carcinoma
  • Non-Small Cell Lung Carcinoma
  • Small Cell Lung Carcinoma
  • Stage III Lung Cancer AJCC v8
  • Stage IIIA Lung Cancer AJCC v8
  • Stage IIIB Lung Cancer AJCC v8
  • Stage IIIC Lung Cancer AJCC v8
  • Solid Tumor

Interventions

DRUG

Porfimer Sodium

Given IV

PROCEDURE

Ultrasound-Guided Transbronchial Needle-Delivered Interstitial Photodynamic Therapy

Undergo EBUS-TBN guided I-PDT

Sponsors & Collaborators

  • National Cancer Institute (NCI)

    collaborator NIH

  • Pinnacle Biologics Inc.

    collaborator INDUSTRY

  • Simphotek Inc.

    collaborator UNKNOWN

  • Roswell Park Cancer Institute

    lead OTHER

Principal Investigators

  • Nathaniel Ivanick, MD · Roswell Park Cancer Institute

Study Design

Allocation
NA
Purpose
TREATMENT
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-02-12
Primary Completion
2024-07-26
Completion
2024-07-26
FDA Drug
Yes

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03735095 on ClinicalTrials.gov