MedTrace Logo

Chemotherapy and Proton Radiation for the Treatment of Locally Advanced Lung Cancer

NCT00614484 · Status: TERMINATED · Phase: PHASE1/PHASE2 · Type: INTERVENTIONAL · Enrollment: 28

Last updated 2014-05-22

Study results available
· View outcomes & findings →

Summary

The purpose of this study is to determine the effectiveness of proton beam radiotherapy combined with chemotherapy for treatment of locally advanced non-small cell lung cancer.

Conditions

  • Locally Advanced Non-Small Cell Lung Cancer

Interventions

RADIATION

Proton Radiation Therapy

A five week coarse of proton radiotherapy begins on day 28 and is given once daily for the first two weeks and twice daily for the final 3 weeks. The total dose given with proton beam is 76 Gy. Weekly chemotherapy with carboplatin and taxol is given during proton therapy.

DRUG

Taxol

200 mg/m2, IV, for 2 cycles followed by 50 mg/m2 weekly for 5 weeks during radiotherapy.

DRUG

Carboplatin

AUC 6, IV, for two cycles followed by AUC 2 weekly for 5 weeks during radiotherapy.

Sponsors & Collaborators

  • Loma Linda University

    lead OTHER

Principal Investigators

  • David A. Bush, MD · Loma Linda University Department of Radiation Medicine

  • Jerry D. Slater, MD · Loma Linda University Department of Radiation Medicine

Study Design

Allocation
NA
Purpose
TREATMENT
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
1999-08-31
Primary Completion
2011-06-30
Completion
2011-06-30

Countries

  • United States

Study Locations

More Related Trials

Entities

Drugs

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00614484 on ClinicalTrials.gov