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Optimal Post Tpa-Iv Monitoring in Ischemic Stroke

NCT03734640 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 4922

Last updated 2025-03-26

No results posted yet for this study

Summary

OPTIMISTmain is an investigator-initiated and conducted, international, multicentre, stepped wedge cluster randomized controlled trial comparing the effects of different intensities of nursing care monitoring for patients with acute ischemic stroke of mild severity and without critical care needs after IV-tPA.

Conditions

  • Acute Ischemic Stroke Patients Receiving Reperfusion Therapy

Interventions

OTHER

Low-intensity monitoring strategy

Post-tpa patients will be monitored in a lower intensity with less vital status and neurological assessment

OTHER

Guideline recommended standard monitoring

Post-tpa patients will be monitored in the usual care monitoring environment

Sponsors & Collaborators

  • Genentech, Inc.

    collaborator INDUSTRY

  • Johns Hopkins University

    collaborator OTHER

  • The George Institute for Global Health, Australia

    collaborator OTHER

  • Craig Anderson

    lead OTHER

Principal Investigators

  • Craig S Anderson, MD PhD · The George Institute

  • Victor C Urrutia, MD · Johns Hopkins University

Study Design

Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
SINGLE
Model
SEQUENTIAL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-04-28
Primary Completion
2024-12-01
Completion
2025-01-23

Countries

  • United States
  • Australia
  • Chile
  • China
  • Malaysia
  • Mexico
  • United Kingdom

Study Locations

More Related Trials

Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03734640 on ClinicalTrials.gov