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Functional Magnetic Resonance Imaging of ATP Cough in Chronic Cough Patients

NCT03722849 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 58

Last updated 2024-08-22

Study results available
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Summary

Persistent cough is a distressing symptom for people with respiratory disorders. Patients also often experience an ongoing urge-to-cough that prompts coughing, and which fails to resolve the sensation. Understanding how the brain controls cough and the urge-to-cough could lead to new cough suppressing therapies. The overall objective of this project is to use functional brain imaging (fMRI) to identify brain regions that are involved in the exaggerated urge-to-cough in humans with chronic cough. Our focus will be on the brainstem where information from the airways first arrives in the central nervous system.

Conditions

Interventions

DRUG

Adenosine Triphosphate

Participants will inhale escalating concentrations of Adenosine Triphosphate (ATP) to induce cough and the urge-to-cough

DRUG

Capsaicin

Participants will inhale escalating concentrations of capsaicin to induce cough and the urge-to-cough

OTHER

Functional Brain Imaging

Participants will have scans of their brain activity using 3 Tesla (3T) brainstem restricted functional brain imaging (fMRI)

Sponsors & Collaborators

  • Imperial College London

    collaborator OTHER

  • Queen's University, Belfast

    collaborator OTHER

  • Monash University

    collaborator OTHER

  • Stuart Mazzone

    lead OTHER

Principal Investigators

  • Stuart Mazzone, PhD · University of Melbourne

Study Design

Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2019-03-01
Primary Completion
2022-05-13
Completion
2022-05-13

Countries

  • Australia

Study Locations

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Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03722849 on ClinicalTrials.gov