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The Bern Heart and Brain Interaction Study - Interaction Between Brain and Heart in Acute Ischemic Stroke

NCT03720522 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 220

Last updated 2024-11-22

No results posted yet for this study

Summary

Acute ischemic stroke is caused by blockage of blood vessels in the brain. Blood vessels can be obstructed by several different mechanisms and identification of this cause is essential to minimize the risk of recurrence.

Conditions

  • Acute Stroke

Interventions

PROCEDURE

Short cardiovascular MRI (CMR)

A short CMR without additional contrast administration will be performed immediately after the routine brain MRI (at admission or after 24h).

PROCEDURE

Adenosine-perfusion cardiovascular MRI (CMR)

An adenosine-perfusion CMR using contrast medium (gadolinium) will be performed in all patients (except group 1) between 48h and 6 days after admission.

PROCEDURE

Blood draw

The following study-specific parameters will be tested: neuropeptide Y 1-36, neuropeptide Y 3-36, total plasma metanephrines, metabolomics analysis Time points for blood draw: at admission (routine), 3h (routine), 24h (routine), 48h, 72h and 3 months.

PROCEDURE

Urine (collection over 24h)

The following study-specific parameters will be tested: catecholamines. Time points for collection: at 24h, 72h, and 3 months

Sponsors & Collaborators

  • Insel Gruppe AG, University Hospital Bern

    lead OTHER

Principal Investigators

  • Simon Jung, PD Dr. med. · Dep. of Neurology, Inselspital Bern

Eligibility

Min Age
18 Years
Max Age
86 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2018-12-01
Primary Completion
2025-12-31
Completion
2026-12-31

Countries

  • Switzerland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03720522 on ClinicalTrials.gov