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Collateral Circulation to LAD and Wellens Sign

NCT03707626 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 1500

Last updated 2018-10-16

No results posted yet for this study

Summary

Overall Aim Coronary artery disease significantly contributes to morbidity and mortality in the United States. Atherosclerotic disease can lead to stenosis of the coronary arteries and subsequent cardiac hypoperfusion. Patients with a critical stenosis of the LAD, potentially leading to acute anterior wall myocardial infarction, may be asymptomatic at presentation with subtle EKG changes as its only manifestation. It is imperative for physicians to recognize patients with new T wave inversions in leads V2-V3 as the standard course of management may lead to poor prognosis.

The purpose of this study is to determine if collateral circulation to the left anterior descending (LAD) artery will mask the presence of a Wellens sign and therefore diminish its diagnostic utility. The conclusion of this study would raise awareness for physicians in light of an absent Wellens sign.

Hypothesis The presence of coronary collateral circulation to the LAD masks the presence of a Wellens sign (both Type 1 and Type 2) in precordial leads V2-V4.

Conditions

  • Coronary Artery Disease
  • Acute Myocardial Infarction
  • Acute Myocardial Infarction of Anterior Wall
  • Collateral Circulation, Any Site

Interventions

OTHER

Wellens Sign

presence or absence in presence of coronary collaterals to LAD

Sponsors & Collaborators

  • Coney Island Hospital, Brooklyn, NY

    lead OTHER

Principal Investigators

  • George Juang, MD · Coney Island Hospital

Eligibility

Min Age
18 Years
Max Age
89 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2018-09-26
Primary Completion
2019-06-23
Completion
2019-06-23

Countries

  • United States

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03707626 on ClinicalTrials.gov