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Human Cardiac Mitochondria in Acute Endocarditis and Obesity

NCT03690076 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 90

Last updated 2019-02-04

No results posted yet for this study

Summary

Data about human cardiac mitochondria are cruelly lacking in the literature. However, damages of the activity of these organelles are often the source of abnormal cardiac function in several pathologies. The purpose of this study is to develop a model of purified human cardiac mitochondria, to verify the purity of these organelles and to validate the authenticity of their function in acute endocarditis and obesity, two situations known to alter their activity. Animal studies have shown that microbial infection reduced mitochondrial metabolism whereas obesity increases it. The investigator's hypotheses are the following: 1) acute endocarditis, a form of cardiac microbial infection, reduces the function of human cardiac mitochondria; 2) obesity (body mass index \> 30) activates the metabolism of human cardiac mitochondria.

Conditions

Interventions

OTHER

Endocarditis

Comparison : Endocarditis vs. control

OTHER

Obese vs. control

Comparisons : Obese vs. control

Sponsors & Collaborators

  • Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement

    collaborator OTHER

  • Université d'Auvergne

    collaborator OTHER

  • Auvergne/Rhône-Alpes area

    collaborator UNKNOWN

  • Heart and Research Foundation

    collaborator UNKNOWN

  • University Hospital, Clermont-Ferrand

    lead OTHER

Principal Investigators

  • Kasra AZARNOUSH · University Hospital, Clermont-Ferrand

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2018-10-09
Primary Completion
2020-04-30
Completion
2020-09-30

Countries

  • France

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03690076 on ClinicalTrials.gov