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Integrated Mapping of Skin-presenting Neglected Tropical Diseases in Liberia

NCT03683745 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 56285

Last updated 2024-06-10

No results posted yet for this study

Summary

Appropriate targeting of interventions for neglected tropical diseases (NTDs) that require innovative and intensified disease management (IDM) requires accurate data on the distribution of these diseases within endemic countries. In most instances however, existing case register data generated through national health management information systems or during programmatic activities do not provide an accurate representation of the true burden of IDM NTDs. This study will pilot a cluster randomized screening and confirmation survey to estimate the burden of IDM NTDs characterised by skin conditions associated with long-term disfigurement and disability. These include: leprosy, Buruli ulcer, yaws and lymphoedema and hydrocele resulting from lymphatic filariasis. The survey is being conducted in one county in Liberia.

The protocol involves community-level screening by community health volunteers trained to use photo-based visual aids to recognise changes in the skin that broadly indicates patent infection. All suspected cases will be verified in their homes by local and national experts trained in the diagnosis of skin-presenting NTDs. The survey will generate accurate district-level prevalence estimates of leprosy, yaws, Buruli ulcer and lymphatic filariasis-associated lymphoedema and hydrocele and quantify the total costs and cost per case detected. In addition, results from this protocol will be compared with routinely collected case register data, to better understand how health system records reflect the true disease situation on the ground and quantify unmet need.

Conditions

  • Leprosy
  • Buruli Ulcer
  • Yaws
  • Lymphatic Filariases

Sponsors & Collaborators

  • AIM Initiative

    collaborator UNKNOWN

  • Ministry of Health, Liberia

    collaborator OTHER

  • London School of Hygiene and Tropical Medicine

    lead OTHER

Principal Investigators

  • Rachel L Pullan, PhD · London School of Hygiene and Tropical Medicine

  • Karsor Kollie, MSc · Ministry of Health, Liberia

Eligibility

Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2018-06-14
Primary Completion
2018-10-30
Completion
2018-12-30

Countries

  • Liberia

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03683745 on ClinicalTrials.gov