Improving Cognition in People With Progressive Multiple Sclerosis Using Aerobic Exercise and Cognitive Rehabilitation

Summary

Given that up to 70% of people with secondary progressive MS are cognitively impaired, the search for effective treatments is considered a priority by people living with the disease. This proposal will address the effectiveness of cognitive rehabilitation (CR) and exercise, either alone, or in combination in this regard. A team of MS researchers has been assembled from the USA, Canada, the United Kingdom, Italy, Denmark, Germany and Belgium for this. A total of 360 people with progressive MS will make up the sample. Brain MRIs will be undertaken in a third of the sample before and after the 12 weeks of treatment to document the functional changes that are expected to occur with symptom improvement.

Conditions

• Multiple Sclerosis, Primary Progressive
• Cognitive Impairment

Interventions

OTHER

Cognitive Rehabilitation

RehaCom software Information processing speed and attention modules

OTHER

Sham Exercise

Sets of balance and stretching exercises

OTHER

Sham Cognitive Rehabilitation

Kompozer software 24 session module consisting of basic internet searches

OTHER

Aerobic Exercise

Recumbent NuStep Bike Aerobic cycling

Sponsors & Collaborators

• University of Florence

  collaborator OTHER

• Fondazione Italiana Sclerosi Multipla

  collaborator OTHER

• University College, London

  collaborator OTHER

• Kessler Foundation

  collaborator OTHER

• University of Alabama at Birmingham

  collaborator OTHER

• University of Southern Denmark

  collaborator OTHER

• Hasselt University

  collaborator OTHER

• University of Plymouth

  collaborator OTHER

• Universita degli Studi di Genova

  collaborator OTHER

• Unity Health Toronto

  collaborator OTHER

• Ospedale San Raffaele

  collaborator OTHER

• Sunnybrook Health Sciences Centre

  lead OTHER

Principal Investigators

• Anthony Feinstein, MD · Sunnybrook Health Sciences Centre

Study Design

Allocation

RANDOMIZED

Purpose

OTHER

Masking

DOUBLE

Model

SEQUENTIAL

Eligibility

Min Age

25 Years

Max Age

65 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2019-03-18

Primary Completion

2022-10-30

Completion

2023-02-03

Countries

• Canada

Study Locations