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Investigation of Nicotine Seeking Behavior in Current Smokers

NCT03670212 · Status: COMPLETED · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 21

Last updated 2018-09-13

No results posted yet for this study

Summary

In this study, 21 non-treatment-seeking cigarette smokers were recruited to investigate the effects of acute stress on brain function and nicotine seeking/self-administration behavior.

Conditions

  • Cigarette Smoking

Interventions

DRUG

Yohimbine Hydrochloride

54mg of yohimbine powder was encapsulated in a generic opaque capsule and swallowed with water.

DRUG

Hydrocortisone

10mg hydrocortisone was encapsulated in a generic opaque capsule and swallowed with water.

DRUG

Lactose Monohydrate Powder

Lactose powder was encapsulated in generic opaque capsules identical to those used during the acute stress session. Lactose doses weighed the same as the acute stress session doses (54mg and 10mg, respectively).

Sponsors & Collaborators

  • National Institute on Drug Abuse (NIDA)

    collaborator NIH

  • Wayne State University

    lead OTHER

Principal Investigators

  • Eric A Woodcock, PhD · Wayne State University

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Model
SINGLE_GROUP

Eligibility

Min Age
21 Years
Max Age
35 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2016-01-07
Primary Completion
2016-10-04
Completion
2016-10-04
FDA Drug
Yes

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03670212 on ClinicalTrials.gov