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Radiofrequency Ablation: Treatment for Posterior Element Pain From Vertebral Compression Fractures

NCT03651804 · Status: WITHDRAWN · Phase: PHASE4 · Type: INTERVENTIONAL

Last updated 2025-07-16

No results posted yet for this study

Summary

The purpose of this study is to test the efficacy of radiofrequency ablation of the medial branch nerves (RFA-MBN) in relieving pain and improving physical function in patients with subacute and chronic vertebral compression fractures (VCF).

Conditions

  • Vertebral Compression Fracture
  • Facet Joint Pain

Interventions

PROCEDURE

Radiofrequency ablation of the medial branch nerves

A radiofrequency ablation (RFA) is a procedure in which a heat lesion via a needle is created on the nerve that transmits the pain signal in order to interrupt the brain to interrupt the painful signal to the brain. We will target the medial branch nerves.

DRUG

Non-steroidal anti-inflammatory drugs

Some of the most commonly used pain medicines in adults. NSAIDs block proteins, called enzymes, in the body that play a role in pain and inflammation. They include aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), and many other generic and brand name drugs.

DRUG

Bisphosphonates

A class of drugs that prevent the loss of bone density and are used to treat osteoporosis and similar diseases.

DRUG

Acetaminophen

A medicine used to treat pain and fever. It is typically used for mild to moderate pain relief. Commonly known as Tylenol.

BEHAVIORAL

Physical therapy

Physical Therapy.

DRUG

Opioids

Opioids are narcotics that act on opioid receptors to produce morphine-like effects and medically they are primarily used for pain relief.

Sponsors & Collaborators

  • University of California, Davis

    lead OTHER

Principal Investigators

  • David Copenhaver, MD · UC Davis Medical Center, Department of Anesthesiology and Pain Medicine

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
90 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2019-04-10
Primary Completion
2023-12-19
Completion
2023-12-19
FDA Drug
Yes

Countries

  • United States

Study Locations

More Related Trials

Entities

Drugs

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03651804 on ClinicalTrials.gov