Study to Evaluate the Reliability and Validity of the Modified Manual Muscle Test for Persons With MS

Summary

Many patients with multiple sclerosis (MS) are treated with physiotherapy. Muscle weakness is a common symptom. It can be evaluated with a variety of muscle function tests. In MS patients, testing muscle function can be confounded by many factors, such as spasticity and ataxia, which are not considered by the existing tests and may cause biased test results. Steinlin Egli described a Modified Manual Muscle Test (MMMT) that considers spasticity and may provide a more reliable and valid muscle function test for MS patients.

The investigators aim to evaluate the inter- and intra-rater reliability of the Modified Manual Muscle Test in MS and evaluate the validity of the Modified MMT according to the criteria of the 6 level British Medical Research Council (BMRC) manual muscle test and the microFET2 handhold dynamometer.

Conditions

• Multiple Sclerosis

Interventions

DIAGNOSTIC_TEST

Modified Manual Muscle Test

Manual Muscle Testing Grading System from 0=No visible or palpable contraction to 5= full range of movement against gravity, maximal resistance

DIAGNOSTIC_TEST

BMRC manual muscle test

muscle scale grades muscle power on a scale of 0 to 5 in relation to the maximum expected for that muscle

DIAGNOSTIC_TEST

MicroFET2 handhold dynamometer

MicroFET 2 Handheld Dynamometer is a force evaluation testing device to evaluate the strength of various muscle groups

DIAGNOSTIC_TEST

Modified Tardieu Scale

Modified Tardieu Scale is to measure if there is spasticity present in a person's muscle and its response to movement

DIAGNOSTIC_TEST

Fatigue Scale for Motor and Cognitive Functions

Measures cognitive and motor fatigue for people with MS

DIAGNOSTIC_TEST

numeric rating scale Fatigue

visual analog scale that uses a scalar numbering system to objectify a patient's fatigue (0 = no fatigue; 10 = most extreme fatigue)

Sponsors & Collaborators

• University Hospital, Basel, Switzerland

  collaborator OTHER

• Physiotherapie Langmatten Binningen, Switzerland

  collaborator UNKNOWN

• Clinical Trial Unit, University Hospital Basel, Switzerland

  collaborator OTHER

• Nanco van der Maas

  lead OTHER

Principal Investigators

• Nico van der Maas · Institute for Physiotherapy Research, Biel, Switzerland

• Marcus Dsouza, Dr. med. · University Hospital Basle, Basle, Switzerland

• Regula Steinlin Egli · Specialized Group Physiotherapy in MS, Binningen, Switzerland

Study Design

Allocation

RANDOMIZED

Purpose

DIAGNOSTIC

Masking

SINGLE

Model

CROSSOVER

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2018-08-01

Primary Completion

2018-12-15

Completion

2019-01-29

Countries

• Switzerland

Study Locations