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The Effect of Transjugular Intraheptic Portosystemic Shunt (TIPS) on Gastrointestinal Motility and the Gut Microbiota

NCT03599492 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 14

Last updated 2022-08-09

No results posted yet for this study

Summary

The effect of portal hypertension on gastrointestinal motility, and how reversal or improvement in portal hypertension may alter gastrointestinal motility, remains unclear and further research is needed. Additionally, patients with cirrhosis have altered gut microflora, particularly rich in lactobacilli, including enterococci and bifidobacteria. Transjugular Intraheptic Portosystemic Shunting (TIPS) is a procedure performed by interventional radiologists, in which a connection is made between the portal and venous circulations, allowing high pressure portal blood to more easily enter the systemic circulation and bypass the liver; thus effectively decreased portal pressure.

Conditions

  • Cirrhosis

Interventions

DIAGNOSTIC_TEST

SMART Pill Pre-TIPS

Assessment of motility with Smart Pill, which will be read and confirmed by gastroenterologist trained to interpret motility studies

DIAGNOSTIC_TEST

SMART Pill Post TIPS

Assessment of motility with Smart Pill, which will be read and confirmed by gastroenterologist trained to interpret motility studies

Sponsors & Collaborators

Principal Investigators

  • Bedros Taslakian, MD, EBIR · NYU Langone Health

Eligibility

Min Age
18 Years
Max Age
99 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2016-11-30
Primary Completion
2022-04-12
Completion
2022-04-12

Countries

  • United States

Study Locations

More Related Trials

Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03599492 on ClinicalTrials.gov