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Amylin and CGRP Head to Head Provocation in Migraine Without Aura Patients

NCT03598075 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 36

Last updated 2020-06-25

No results posted yet for this study

Summary

Amylin and calcitonin gene related peptide (CGRP) are related to the same peptide family. Both share 16 out of 37 amino acids and can activate each others receptor. CGRP is implicated in migraine pathophysiology but the role of Amylin and its receptor in migraine is not fully clarified.

Conditions

  • Migraine Without Aura

Interventions

OTHER

Amylin (Pramlintide)

Pramlintide is a amylin analog. It will be given intravenously at the rate of 120 micrograms over 20 minutes .

OTHER

CGRP

CGRP It will be given intravenously at the rate of 30 microgram over 20 minutes.

Sponsors & Collaborators

  • Danish Headache Center

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
OTHER
Masking
TRIPLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
60 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2018-07-01
Primary Completion
2019-09-30
Completion
2019-12-31

Countries

  • Denmark

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03598075 on ClinicalTrials.gov