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Safety and Efficacy of Adding Intravenous N-acetyl Cysteine in Colon Surgeries

NCT03589495 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 60

Last updated 2018-07-18

No results posted yet for this study

Summary

The use of antioxidant agents in the prevention or decreasing the severity of postoperative systemic inflammatory response syndrome after colonic surgeries adopted nowadays. Therefore, it is of interest to investigate safety and efficacy of administrating short term intravenous (IV) N acetyl cysteine as add on to l alany l glutamine and total parenteral nutrition on the marker of oxidative stress malondialdehyde and anti- inflammatory marker tumor necrosis factor alpha in patients undergoing colonic surgeries through a prospective, randomized, double blinded, controlled clinical trial

Conditions

  • Systemic Inflammatory Response Syndrome

Interventions

DRUG

N Acetyl L Cysteine

100 mg/kg n acetyl cysteine dissolved in dextrose5%

OTHER

dextrose 5%

Sponsors & Collaborators

  • Ain Shams University

    lead OTHER

Principal Investigators

  • manal elhammsy, prof · Ain Shams University , faculty of pharmacy

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2015-07-30
Primary Completion
2016-10-15
Completion
2016-10-15

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03589495 on ClinicalTrials.gov