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Early Detection of Imaging-derived Subclinical Cardiac Injuries

NCT03575650 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 148

Last updated 2024-02-28

No results posted yet for this study

Summary

Breast cancer (BC) radiotherapy leads to incidental cardiac irradiation, resulting in an increased risk of various major cardiac events (MCEs). In addition, recent studies indicate that for the treatment of BC, the addition of chemotherapy further enhances the risk of MCEs. Information regarding morphological and functional early subclinical cardiac injuries (ESCIs) induced by chemotherapy and radiotherapy that develop into MCEs is largely lacking in scientific literature. This information is essential towards the development of primary and secondary preventive strategies. The EMIRA prospective cohort has as main objective to identify morphological and functional ESCIs in BC patients treated with adjuvant radiotherapy and chemotherapy.

Conditions

Interventions

OTHER

Cardiac imaging modalities

Repeat cardiac echocardiographies, MRI-scans and CT-scans for early subclinical biomarker assessments in breast cancer patients treated with chemotherapy and radiotherapy

Sponsors & Collaborators

  • Utrecht University

    collaborator OTHER

  • University Medical Center Groningen

    lead OTHER

Principal Investigators

  • Hans Langendijk, Prof.Dr · UMCG

Eligibility

Min Age
40 Years
Max Age
70 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2019-01-24
Primary Completion
2024-09-02
Completion
2024-09-02

Countries

  • Netherlands

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03575650 on ClinicalTrials.gov