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Effects of Intraoperative Normal Saline vs Lactated Ringer on Outcomes in Pediatric Liver Transplantation

NCT03563378 · Status: UNKNOWN · Phase: NA · Type: INTERVENTIONAL · Enrollment: 200

Last updated 2018-06-20

No results posted yet for this study

Summary

Lactated Ringer(LR) has been extensively used to maintain and replace intravascular volume in a variety of anesthetic procedures. However, the utility of LR in pediatric with hepatic failure undergoing liver transplantation is unclear, because addition of exogenous lactate may increase lactate concentration. In addition,large amounts of normal saline(NS) which does not contain lactate can induce a hyperchloremic metabolic acidosis and have been asociated with adverse effects on kidney injury, coagulation, and death. Accordingly, the investigators performed a double-blinded randomized trial comparing the effects of intraoperative NS or LR on outcomes in pediatric receiving Liver transplantation.

Conditions

  • Biliary Atresia Intrahepatic Syndromic Form

Interventions

DRUG

Lactated Ringer

Patients will be administered Lactated Ringer's solution for intraoperative fluid management.

DRUG

Normal saline

Patients will be administered normal saline for intraoperative fluid management.

Sponsors & Collaborators

  • RenJi Hospital

    lead OTHER

Principal Investigators

  • qi lu, Dr. · Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
3 Months
Max Age
6 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2018-07-28
Primary Completion
2020-05-27
Completion
2020-05-27

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03563378 on ClinicalTrials.gov