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Effect of Steroid Administration on Maternal Blood Levels of hLPCAT1 mRNA

NCT03562182 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 80

Last updated 2021-10-05

No results posted yet for this study

Summary

Neonatal respiratory distress syndrome affects babies who are born preterm and requires them to be placed on a ventilator in the Intensive Care Unit. Over 15 million babies were born premature and these numbers have been increasing. It is caused by lungs which are still too immature to produce adequate amounts of surfactant. This surfactant reduces the alveolar surface tension and maintains the alveoli from collapsing. Collapsed alveoli prevent gas exchange and greatly increase work of breathing. Surfactant is a biochemical complex made up mostly of phospholipids such as phosphatidylcholine and phosphatidylglycerol and these, in turn, appear to be synthesized by lysophosphatidylcholine acyltransferase 1 (LPCAT 1). The investigators have previously established that hLPCAT1 mRNA in maternal serum correlates with lamellar body count, a well established clinical marker of fetal lung maturity.

Conditions

  • Fetal Lung Maturity
  • Respiratory Distress Syndrome in Premature Infant

Interventions

OTHER

blood draw

Blood draw (2.5mL) to assess mRNA LPCAT1 levels

Sponsors & Collaborators

  • Wayne State University

    lead OTHER

Principal Investigators

  • Maurice Recanati, MD · Assistant Professor OBGYN

Eligibility

Min Age
18 Years
Max Age
40 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2018-06-18
Primary Completion
2022-05-31
Completion
2022-05-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03562182 on ClinicalTrials.gov