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Tidal Volume Challenge and Reliability of Plethysmography Variability Index

NCT03546179 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 48

Last updated 2020-07-07

No results posted yet for this study

Summary

The aim of this study is to investigate whether a temporary increase in tidal volume can predict fluid responsiveness in patients receiving a low tidal volume ventilation in hepatobiliary and pancreatic surgeries.

The hypothesis of this study is that a temporary increase in tidal volume from 6 to 8 ml/kg would improve the predictability of PVI in patients receiving low tidal volume ventilation in surgical procedures with large fluid shift as hepatobiliary and pancreatic procedures.

Conditions

  • Abdominal Cancer

Interventions

OTHER

tidal volume challenge test

Tidal volume (VT) will be increased from 6 to 8 ml/kg of for one minute and hemodynamic variables, including PVI with 8 ml/kg tidal volume ventilation (PVI8) will be recorded.

OTHER

Volume loading

After these two baseline hemodynamic measurements, volume expansion will be performed for 10 min using an infusion of balanced crystalloid solution (6ml/kg of predicted body weight).

Sponsors & Collaborators

  • Fayoum University Hospital

    lead OTHER

Principal Investigators

  • Magdy K Mohamed Khalil, M.D · National Liver Institute, Menoufia University

  • Mohamed F Mohamed El-Gayar, M.D · Faculty of medicine, Fayoum University

  • Joseph M Botros, M.D · Faculty of medicine, Fayoum University

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2018-08-01
Primary Completion
2020-01-15
Completion
2020-02-15

Countries

  • Egypt

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03546179 on ClinicalTrials.gov