The Effect of Soursop Supplementation on Blood Pressure, Serum Uric Acid and Kidney Function in Prehypertensive Patients

Summary

This study was a randomized controlled trial study. The aim of this study was to determine the effect of soursop fruit supplementation on blood pressure (BP), serum uric acid (SUA), and kidney function.

The definition of prehypertension and hypertension was accepted as delivered in The Seventh Report of the Joint National Committee (JNC 7) as the systolic BP was 120 - 139 mmHg and diastolic BP was 80 - 89 mmHg for prehypertension, while systolic BP ≥ 140 mmHg or diastolic BP ≥ 90 mmHg for hypertension.

Based on the study by Sja'bani (2014), the cut-off point of (SUA) was divided into 3 categories, which are normal (\< 5 mg/dL), high-normal (5 - \<7 mg/dL), and high (≥ 7 mg/dL).

A number of 143 people with essential prehypertension and high normal uric acid level were assigned as subject in this study. Subjects were randomly assigned into two groups which are treatment and control group. For a 3 months period, the treatment group was given 2x100 g soursop fruit juice per day and the control group was left without treatment.

Blood pressure was measured by medical team using Omron HEM-907 (digital automatic blood pressure monitoring) every 2 weeks (3 times readings for each) in each subject's home. Subjects were examined in sitting position. Evaluation of laboratory examination was taken at week 0, 7 and 13.

Conditions

• Blood Pressure
• Prehypertension
• Uric Acid

Interventions

DIETARY_SUPPLEMENT

Soursop supplementation

The soursop supplementation was given to treatment group (with soursop group) 2 times a day for 100 g each for 3 months period.

OTHER

Placebo

Control group (without soursop group) was left without treatment during study period

Sponsors & Collaborators

• Mlati Study Group, Faculty of Medicine, Gadjah Mada University

  collaborator UNKNOWN

• Gadjah Mada University

  lead OTHER

Principal Investigators

• Mochammad Sja'bani, PhD · Department of Internal Medicine, Faculty of Medicine, University of Gadjah Mada

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

30 Years

Max Age

59 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2017-07-10

Primary Completion

2018-01-12

Completion

2018-01-19

Countries

• Indonesia

Study Locations