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Mediator Release During Exercise-induced Bronchoconstriction

NCT03524053 · Status: UNKNOWN · Phase: NA · Type: INTERVENTIONAL · Enrollment: 12

Last updated 2019-01-29

No results posted yet for this study

Summary

This study will compare the inflammatory response in induced vs inhibited exercise induced bronchoconstriction (EIB) in patients with a medical diagnosis of asthma/EIB. Urinary and plasma samples will be analysed to compare the mediator release in each condition, alongside changes in lung function.

Conditions

  • Exercise Induced Asthma

Interventions

OTHER

Exercise induced bronchoconstriction

Participants will exercise whilst inhaling dry-air, this is known to exacerbate the bronchoconstrictive response.

OTHER

Inhibited EIB

Participants will perform the exercise-test whilst inhaling warm-humid air. This is known to inhibit the EIB response and will provide a direct comparison group for the EIB condition.

Sponsors & Collaborators

Principal Investigators

  • Hannah Marshall, MSc · Brunel University

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
50 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2018-11-01
Primary Completion
2020-03-31
Completion
2020-03-31

Countries

  • United Kingdom

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03524053 on ClinicalTrials.gov