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Tailored Axillary Surgery With or Without Axillary Lymph Node Dissection Followed by Radiotherapy in Patients With Clinically Node-positive Breast Cancer (TAXIS)

NCT03513614 · Status: ACTIVE_NOT_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 1500

Last updated 2026-05-01

No results posted yet for this study

Summary

RATIONALE: The use of tailored axillary dissection as a tailored procedure will avoid surgical overtreatment by selectively removing the lymph nodes that are affected by the cancer, thereby sparing many women the unnecessary complications of a radical surgery, providing a better quality of life while keeping the same efficacy.

PURPOSE: The phase III trial is evaluating the optimal treatment for breast cancer patients in terms of surgery and radiotherapy.

Conditions

  • Node-positive Breast Cancer

Interventions

PROCEDURE

Tailored axillary surgery - both Arms

Axillary lymph node dissection - Arm A

RADIATION

Radiotherapy - Arm A

Regional nodal irradiation excluding the dissected axilla - Arm A

RADIATION

Radiotherapy - Arm B

Regional nodal irradiation including the full axilla - Arm B

Sponsors & Collaborators

  • ETOP IBCSG Partners Foundation

    collaborator NETWORK

  • Austrian Breast Cancer Study Group

    collaborator OTHER

  • University Hospital, Basel, Switzerland

    lead OTHER

Principal Investigators

  • Walter P. Weber, Prof. · University Hospital, Basel, Switzerland

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2018-08-07
Primary Completion
2029-12-31
Completion
2036-12-31

Countries

  • United States
  • Argentina
  • Austria
  • Canada
  • Croatia
  • Germany
  • Greece
  • Hungary
  • Italy
  • Latvia
  • Lithuania
  • South Korea
  • Switzerland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03513614 on ClinicalTrials.gov