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Chemotherapy Plus Surgery in Treating Women With Breast Cancer

NCT00003013 · Status: COMPLETED · Phase: PHASE3 · Type: INTERVENTIONAL · Enrollment: 450

Last updated 2013-09-17

No results posted yet for this study

Summary

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining surgery with chemotherapy may kill more tumor cells. It is not yet known which treatment regimen is more effective for breast cancer.

PURPOSE: Randomized phase III trial to study the effectiveness of chemotherapy plus surgery in treating women who have breast cancer.

Conditions

Interventions

DRUG

CMF regimen

DRUG

cyclophosphamide

DRUG

doxorubicin hydrochloride

DRUG

fluorouracil

DRUG

methotrexate

DRUG

paclitaxel

DRUG

tamoxifen citrate

PROCEDURE

conventional surgery

RADIATION

radiation therapy

Sponsors & Collaborators

  • Fondazione IRCCS Istituto Nazionale dei Tumori, Milano

    lead OTHER

Principal Investigators

  • Gianni Bonadonna, MD · Fondazione IRCCS Istituto Nazionale dei Tumori, Milano

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT

Eligibility

Min Age
18 Years
Max Age
70 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
1996-10-31
Completion
2009-03-31

Countries

  • Austria
  • Czechia
  • Estonia
  • Germany
  • Hungary
  • Italy
  • Latvia
  • Poland
  • Russia
  • Slovakia
  • Spain

Study Locations

More Related Trials

Entities

Drugs
Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00003013 on ClinicalTrials.gov